About Us

BSIM Therapeutics is a biotech company focused on the design of organ-targeted, high-quality drug candidates for the treatment of transthyretin-mediated amyloidoses. We work closely with patients and physicians to understand and answer to multiple clinical manifestations representing unmet medical needs.


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Rui M. M. Brito, PhD

Co-founder, Member of the Board and Chief Science Officer

BSc in Biochemistry from the University of Coimbra (Portugal). PhD in Biochemistry from Rice University (USA), on NMR studies of protein-ligand interactions and Post-doctoral work at Oxford University (UK). Visiting scientist at the University of Cincinnati (USA), Johns Hopkins University (USA) and the Leibniz-Institut fur Molekulare Pharmakologie (Germany). Associate Professor and group leader of the Protein Biophysical Chemistry group at the University of Coimbra (UC), Director of the NMR spectroscopy platform at UC (UC-NMR) and member of the scientific board of the NMR national network (PTNMR).

Key areas of expertise: protein structure, stability, folding and aggregation, with special emphasis on the molecular mechanisms of neurodegenerative amyloid pathologies.

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Carlos J. V. Simões, PharmD, PhD

Co-founder, Member of the Board and Chief Technology Officer

PharmD and PhD in Chemistry from the University of Coimbra (Portugal). PhD work at University of Leeds (UK), on Computational Drug Discovery. Research fellow at PRACE, the Partnership for Advanced Computing in Europe.

Key areas of expertise: molecular modeling, cheminformatics and virtual ligand screening, molecular dynamics, protein-ligand interactions, lead discovery and optimization.

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Rita Videira, PharmD, PhD

Project, Communication and Regulatory Affairs Manager

PharmD, MSc in Pharmaceutical Biotechnology and PhD in Pharmaceutical Sciences from University of Coimbra (Portugal). PhD work on Drug discovery for Alzheimer’s disease.

Key areas of expertise: project planning, writing and management; field experience in clinical trials, medical and regulatory affairs.

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João Meireles, PhD

Applied Mathematician and Data Scientist

BSc in Mathematics from University of Lisbon (Portugal) and PhD in Mathematics from University of Padova (Italy) on Stochastic Optimal Control Problems and Viscosity Solutions.

Key areas of expertise: Mathematical optimization, probability and statistics, data mining and machine learning.

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Catarina A. Carvalheda, PhD

Computational Chemist

BSc and MSc in Biochemistry from University of Lisbon (UL) and PhD in Computational Biophysics from University of Dundee (UoD). PhD work on Simulation studies of structure-function relationship of two biological processes: proton pumping in cbb3 oxidase and activation of Parkin.

Key areas of expertise: cheminformatics, protein modeling, molecular dynamics, quantum mechanics calculations, protein-ligand interactions.

Advisory Board

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Maria João Saraiva, PhD

BSc in Biology from University of Porto (Portugal), MSc in Biochemistry from University of London (UK) and PhD in Biochemistry from University of Porto (Portugal). Group Leader of the Molecular Neurobiology group of the Institute for Molecular and Cell Biology (IBMC) and Full Professor at University of Porto. Recognized leader in the field of neurodegenerative diseases, in particular, Familial Amyloidotic Polyneuropathy (FAP). Coordinator of several international scientific projects. Receiver of the Gulbenkian Science Award in 2009.

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Ole Suhr, MD, PhD

MD from University of Copenhagen (Denmark), PhD in Gastroenterology from Umeå University Hospital (Sweden). Chief Physician and Gastroenterologist at the Department of Medicine and Head of the Amyloid team at the Umeå University Hospital. Participation in several clinical trials for transthyretin (TTR) amyloidosis. Member of the Advisory Board of the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR).

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João Melo Beirão, MD, PhD

MD and PhD in Ophthalmology from the University of Porto (Portugal). Adjunct Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) and Physician at Santo António (Centro Hospitalar do Porto) and CUF Hospitals (Porto). Recognized leader in oculopathy associated to FAP (hATTR-PN) and expert in vitreous and retina surgery.

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Eric Leire, MD, MBA

MD from Grenoble University (France) and MBA from Northwestern University (USA). Chief Executive Officer (CEO) at Enochian Biosciences Inc. (former DanDrit Biotech USA Inc.), partner of BIOFUND Venture Capital (Finland and Denmark) and Medwell Capital Corp (Canada). Extensive experience and record of licensing deals in the Biotech and Pharma sector (Pfizer, Schering-Plough and Pharmacia, among others).

Partners & Investors

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